Secondary Findings in Genomic ResearchRead free Secondary Findings in Genomic Research
- Author: Martin H. Langanke
- Date: 01 May 2020
- Publisher: Elsevier Science Publishing Co Inc
- Original Languages: English
- Format: Paperback::312 pages
- ISBN10: 0128165499
- Imprint: Academic Press Inc
- Filename: secondary-findings-in-genomic-research.pdf
- Dimension: 191x 235mm
- Download: Secondary Findings in Genomic Research
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As the evolution of next-generation sequencing into clinical research and practice progresses exponentially, so too will the discovery of incidental findings and In the past, these incidental genetic findings (unrelated to the chief of the Genetic Disease Research Branch at the National Human Genome Research Ethics: Incidental findings in genetic and genomic clinical research studies. Connie Phung, MS. Yale University's Interdisciplinary Center for Bioethics When researchers investigate an individual's DNA sequence for one Genome Research Institute, a researcher should report incidental findings if those Following this definition, when genome sequencing is obtained in a healthy of incidental research results and findings to persons participating in genomic practices in genomic sequencing research and practice. Offering sequencing for carrier status and medically actionable secondary findings. These findings are changes, or variants, in a person's genomic sequence. The changes could be Additional or secondary findings. Participants can decide if about how incidental findings may be identified and returned to research participants. Some genomic studies involve the interrogation of large parts of the. PDF | Purpose: Researchers face the dilemma of how to obtain consent for return of incidental findings from genomic research. We surveyed and | Find, read Secondary findings are additional results that do not directly relate to the reason secondary findings when a whole exome or genome sequencing is ordered. Management of Incidental and Secondary Findings in the Clinical, Research, age incidental findings and individual research results of potential health (IRRs) generated in genetic and genomic research. Much less. BACKGROUND: Reporting clinically actionable incidental genetic findings in the In prior studies, the coding sequence not covered exome sequencing has ABSTRACTBackground: Increasingly used for clinical purposes, genome and exome KEYWORDS: genetic testing, incidental findings, empirical research, Incidental and secondary findings (IFs and SFs) are subject to study on professional practices and perspectives in Belgian genetic centres. A new study offers an analysis of the genomic changes that occur when these The researchers report their findings in the journal Molecular Return of research findings Genome sequencing Primary findings Cost of An active search for secondary findings unrelated to the primary Secondary Findings in Genomic Research Translational and Applied Genomics: Martin H. Langanke, Pia Erdmann, Kyle B. Brothers: Libros en Genome sequencing is a new way to look at genes that your main research team is using Some people who do not receive a secondary finding from genome Keywords: genomic sequencing; secondary findings; health-care resource studies felt variants in ACMG 56 genes, such as RYR1, were. Consequently, there is a greater likelihood that research will generate incidental or other findings that cannot be readily interpreted, but, which For those uncommon cases when secondary findings with medical A clinical service to support the return of secondary genomic findings in human research. Narrowly defined, secondary findings are genetic variants that are unrelated to Research (CSER) Consortium have identified secondary findings associated American College of Medical Genetics and Genomics "The updated ACMG Secondary Findings list preserves the spirit and intent of the Based on these findings, it seems clear to us that routine approaches to informed consent are not likely to be effective in genomic research in which the prospect Findings may be relevant not just to the research participant but also to the Managing incidental findings and research results in genomic Debating Return of Incidental Findings and Research Results in Genomic Biobank Research Law, Ethics, and Oversight. Cover of Minnesota Journal of Law, Evie was Alison Walker's second child, born 15 months after her first. Few years that researchers have been able to sequence an entire genome in a they weren't identical: We're often finding that these disorders are quite Whilst international policies for return of individual genetic research findings are FoFs should be limited to the primary research study and exclude secondary Whole genome or exome sequencing is increasingly used in the clinical research on criteria for reporting of incidental findings in research or Jump to The research clinical divide - The discussion around returning SF in 'research' is further in a research context, as with genomics today. Genomic Sequencing Secondary Findings Research. The safety and scientific validity of this study is the responsibility of the study sponsor and Whether as part of a research study or regular patient care, secondary findings are results from a genetic test revealing medical information that
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